An estimated 5-10% of cancers can be attributed to a germline or constitutional (hereditary) variant
these are referred to as cancer predisposition syndromes. An individual who carries one of these variants is not certain to develop cancer, but they are at a higher risk for having cancer in their lifetime compared to the general population. By identifying patients and families with these variants, screening, prophylactic measures, and specialized treatments can lead to early detection and improved outcomes.
Our laboratory offers over 25 constitutional cancer genetics panels, comprising of select genes based on the patient’s individual and family history of cancer and in accordance with Ontario Health recommendations. For example, our Hereditary Breast and Ovarian Panel includes 11 genes known to be associated with these types of cancers. Patients with a known familial variant may also be tested at our laboratory, so that they may be informed about their cancer risks.
Genetic testing for germline cancer variants must be ordered either by a genetic counsellor, geneticist, or in select cases, by a specially trained oncologist or surgeon. Pre- and post-test genetic counselling is required so that a genetics expert can explain to patients how cancers are inherited, how inheriting certain genetic changes can increase the risk of cancer, as well as the benefits and limitations of genetic testing. In these sessions, patient will learn details and ask questions to ensure they can provide informed consent for testing. If your patient lives in the Greater Hamilton Area, they can be referred to the Cancer Genetics Clinic at Juravinski Hospital for a consult. This testing cannot currently be ordered by non-genetics professionals.
